Mirena-Side-Effects

Case report

A 33-year-old woman, para 2, with a long standing history of menorrhagia, dysmenorrhoea and tiredness was referred by her GP to the hospital (2002). At the time she was treated for anaemia and felt tiredness. Also she was suffering from dysmenorrhoea; her periods had been regular although in the previous few months she was bleeding PV continuously. Her periods had become heavy after sterilisation (1996). She was anaemic. Cervical cytology had always been normal. In the past she had undergone a laparoscopy for pelvic pain for suspected endometriosis (1997), an appendicectomy (1997) and she was diagnosed with duodenal ulcer (1996). For management of her menorrhagia, she opted for Microwave Endometrial Ablation which was done in August 2002. After that she had an ultrasound scan for erratic bleeding which showed irregular endometrium. The patient was booked for hysteroscopy under general anaesthesia. The procedure was attempted in September 2003 and was abandoned due to difficulties passing the hysteroscope through the endocervical canal. The hysteroscopy was repeated in January 2004 and few intrauterine adhesions were reported. A Mirena IUS was inserted under the same general anaesthetic.

A month later she was admitted to the hospital with right upper quadrant pain and a problematic bleeding pattern. Ultrasound at this stage showed a normal size uterus but the Mirena IUS was not obviously in situ. It was assumed the Mirena IUS had fallen out and the patient was booked for vaginal hysterectomy, which was performed in September 2005.

In January 2007 was admitted to the hospital with right upper quadrant pain again and all investigations including chest X-ray, abdominal ultrasound scan and blood tests were normal. She had an upper GI endoscopy which showed a gastric ulcer (Cardia).

Fig.1 Abdominal X-Ray with the Mirena IUS (arrowed).

She was admitted again 1 year later with pelvic pain. An abdominal X-ray showed the lost IUS (fig. 1) and the CT scan showed the IUS to lie anteriorly under the rectus muscles and adjacent to the dome of the bladder. In April 2008 the IUS was retrieved laparoscopically. The omentum was adherent to anterior abdominal wall and the Mirena IUS was found in the omentum, (Fig.2). This was felt to be unlikely to be the cause of the pain. The IUS was removed easily from the abdominal cavity laparoscopically. The right tube and ovary were adherent to right pelvic side and they were freed up. The procedure was uneventful and the patient was discharged the same day and symptom free since.

Discussion

Uterine perforation is a serious, albeit rare, potential complication of Intrauterine contraceptive use. For informed consent, women should be informed that uterine perforation occurs in fewer than 1 in 1000 intrauterine LNG-IUS insertions4 Fig. 2 Mirena IUS (circled) within the omentum.

The rate of perforation reported with the LNG-IUS in a large observational cohort study was 0.9 per 1000 insertions.5 Current guidelines recommend that advice regarding the management of problems arising with the LNG-IUS use4 is similar to that for IUD use3. The problems are suspected perforation, lost threads, abnormal bleeding, pregnancy, presence of actinomyces-like organisms, pelvic infection, and postmenopausal removal.

The Royal College of Obstetricians & Gynaecologists recommends6 that women who present with persistent menorrhagia, despite LNG-IUS use, should be advised to return for further assessment of the uterine cavity (biopsy or ultrasound scan) to exclude pathology.

If menorrhagia persists despite medical treatments, women should be re-examined.6 An assessment of the uterine cavity should be performed using ultrasound scan. An endometrial biopsy should be considered in all women with persistent menorrhagia. When indicated, a hysteroscopy allows the assessment of the uterine cavity and biopsy under local anaesthesia.6 The WHO Selected Practice Recommendations for Contraceptive Use (WHOSPR) 7does not specifically refer to the Mirena IUS. Follow-up 36 weeks following IUD insertion is recommended and the Clinical Effectiveness Unit (CEU) advises similar follow-up for women using the Mirena-IUS.

In this case report, the detection of the Mirena IUS inside the peritoneal cavity was noted nearly 4 years after the insertion and the perforation of the uterus. The patient had several admissions to the hospital under the care of gynaecologists or gastroentero-logists always complaining for upper or lower abdominal pain. She even had a vaginal hysterectomy. Had she undergone an abdominal hysterectomy, the Mirena IUS may have been noted at that time.

This case report clearly demonstrates that following an ultrasound report showing an empty uterus in a symptomatic patient, an abdominal X-ray should be performed to identify whether or not the IUS is inside the peritoneal cavity. Also, we need to be aware of the peritoneal adhesion potential of Mirena IUS it is expected to be low. In another case report8, an intraperitoneal Mirena IUS resulted in plasma levonorgestrel levels 10 times higher (4.7 nmol/l) than the plasma level of levonorgestrel observed with Mirena IUS placed in utero. This high plasma LNG level suppresses ovulation. Therefore, aside from the adhesion potential, a misplaced Mirena IUS should be removed when pregnancy is desired9, 10.

The authors conclude that judicious use of the abdominal X-ray can lead to the early detection of a migrated IUS and expedite early removal.

A thorough literature search of the Medline, Embase and Cochrane databases did not reveal case reports similar to this and also did not report any formal guidance as to the use of the Mirena IUS device following endometrial microwave ablation, but we did find an article regarding insertion of Mirena IUS, after endometrial resection.11

Endometrial resection is a surgical method to manage menorrhagia. Intrauterine scarring may occur following treatment, but it is not known if the risk of uterine perforation is increased.

The Clinical Effectiveness Unit (CEU) responded12 recently that the British National Formulary (BNF)13 suggested that intrauterine devices (IUDs) should be used with caution in severely scarred uteri.

The United Kingdom Medical Eligibility Criteria for Contraceptive Use (UKMEC)14 recommends that if women have a distorted uterine cavity (any congenital or acquired uterine abnormality distorting the uterine cavity in a manner that is incompatible with IUD insertion), then the IUD or the levonorgestrel-releasing intrauterine system (LNG-IUS) should not be used (UKMEC 4).

A narrative review paper on treatment after hysteroscopic surgery suggests that an acceptable post-operative method of contraception after endometrial ablation is the LNG-IUS, as it protects the endometrium and there is a high amenorrhoea rate.15 However, following successful endometrial ablation the uterine cavity is usually severely narrowed making insertion of IUS (or IUD) impossible and it would not normally be considered as an appropriate method in these circumstances. Significant bleeding would suggest failure of the procedure, and if IUS or IUD was to be considered it should only be done with hysteroscopic assistance by an experienced gynaecologist.